期刊
CHIRALITY
卷 21, 期 3, 页码 339-348出版社
WILEY
DOI: 10.1002/chir.20542
关键词
high-performance liquid chromatography (HPLC); chiral stationary phases (CSPs); 3,5-dimethylphenyl-carbamoylated-beta-cyclodextrin-based column (Cyclobond I 2000 DMP); 2,6-dinitro-4-trifluoromethylphenyl-ether-beta-cyclodextrin-based; column (Cyclobond DNP); unusual beta-3-homo amino acids; bicyclic-beta-amino acids
资金
- Hungarian National Science Foundation [K 67563, TS 40888]
- National Institutes of health
- Bolyai Janos
The application of 3,5-dimethylphenyl-carbamoylated-beta-cyclodextrin (Cyclobond I 2000 DMP) and 2,6-dinitro-4-trifluoromethylphenyl-ether-beta-cyclodextrin-based (Cyclobond DNP) chiral stationary phases for the high-performance liquid chromatographic enantioseparation of unusual beta-amino acids is reported. The investigated amino acids were saturated or unsaturated alicyclic beta-3-homo-amino acids and bicyclic beta-amino acids. Prior to chromatographic analyses, all amino acids were transformed to N-3,5-dinitrobenzoyl- or N-3,5-dimethylbenzoyl form to ensure a pi-acidic or pi-basic function and to enhance the pi-acidic-pi-basic interactions between analytes and chiral selectors. Chromatographic results are given as retention, separation and resolution factors. The chromatographic conditions were varied to achieve optimal separation. The sequence of elution of the enantiomers was determined in some cases. Chirality 21:339-348, 2009. (C) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据