期刊
JOURNAL OF INFECTION
卷 70, 期 6, 页码 624-630出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2014.10.016
关键词
Hepatitis E virus; HIV; Seroprevalence; Anti-HEV IgG; Anti-HEV IgM; HEV RNA
资金
- Fundacion Progreso y Salud, Consejeria de Salud de la Junta de Andalucia [0036/2010, PI-157/2011, 430/2012]
- Programa de Intensificacion de la Actividad de Investigacion del Servicio Nacional de salud espanol (I3SNS)
- Consejeria de Salud, Innovacion y Ciencia de la Junta de Andalucia
- Fundacion Progreso y Salud (Consejeria de Salud, Innovacion y Ciencia de la Junta de Andalucia) [RH-0024-2013 CSIPS-POSTDOCTORALES Y GRUPOS]
- Tecnico Superior de Apoyo a la Investigacion en Salud grant from the Ministerio de Ciencia e Innovacion del Gobierno de Espana [PTA-2011-5503-I]
Background & aims: The seroprevalence of the hepatitis E virus (HEV) and its chronicity rate in the HIV-infected population has not been well established. As a result, the magnitude of this emerging disease in this population cannot be established. Methods: Prospective study that included HIV-infected patients followed up between September 2012 and May 2013. All included patients were tested for anti-HEV IgG/IgM. In patients with confirmed anti-HEV IgG/IgM positivity, RT-PCR was performed. In patients where HEV RNA was amplified, a second RT-PCR assay was performed 6 months later to identify transient or chronic HEV infections. Results: Eight hundred and ninety-four HIV-infected patients were enrolled in the study. Of these patients, 399 (44.6%) were monoinfected with HIV; 462 (51.6%) were co-infected with HIV/HCV; 12 (1.3%) were co-infected with HIV/HBV; and 21 (2.3%) were co-infected with HIV/HCV/HBV. In 88 patients, anti-HEV IgG/IgM was detected (seroprevalence: 9.8% [95% CI: 8.02%-11.9%]). In five patients (0.5%; 95% CI: 0.2%-1.2%), HEV RNA was detected; 5.7% (95% CI: 2.1%-12.1%) of the patients were anti-HEV IgG/IgM positive. None of these patients showed detectable HEV RNA six months later. Conclusion: HEV infection is frequent in HIV-infected patients but developing a chronic HEV infection may be considered an uncommon liver disease in this population. (C) 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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