期刊
CHIRALITY
卷 20, 期 3-4, 页码 441-445出版社
WILEY
DOI: 10.1002/chir.20461
关键词
10,11-didehydro Cinchona alkaloids; Cinchona alkaloids; quinine; elimination; alkynes
A revised procedure for the conversion of the four major Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) into their respective 10,11-didehydro derivatives is described. The reported protocol offers several advantages over a recently published synthetic route. These include (i) enhanced robustness (ii) ready scalability (iii) reduced operational complexity and number of steps (iv) chromatography-free work-up. In addition, toxic solvents were replaced by environmentally less problematic alternatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据