期刊
CHINESE SCIENCE BULLETIN
卷 59, 期 10, 页码 936-943出版社
SCIENCE PRESS
DOI: 10.1007/s11434-014-0131-y
关键词
Oct4; Akt; Embryonic stem cells; Embryonal carcinoma cells
资金
- National Natural Science Foundation of China [31271465]
Oct4 is mainly expressed in embryonic stem cells (ESCs), germline stem cells, and embryonal carcinoma cells (ECCs) and plays an indispensable role in maintaining the pluripotency and self-renewal of these pluripotent stem cells. Akt serine/threonine kinase, a well-established anti-apoptosis and cell survival factor, has also been implicated as an important regulator of stemness. Emerging evidence indicated that Oct4 is reciprocally connected to Akt via a number of routes, and moreover, a direct interaction between Oct4 and Akt has recently been revealed. These components collectively form the Akt-Oct4 regulatory circuit. In this review, we summarize our current knowledge about the Akt-Oct4 regulatory circuit in ESCs and discuss its alterations in ECCs that may underlie the tumorigenesis of pluripotent stem cells.
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