期刊
CHINESE SCIENCE BULLETIN
卷 58, 期 34, 页码 4190-4202出版社
SCIENCE PRESS
DOI: 10.1007/s11434-013-5790-6
关键词
family history; urbanization; epigenetics; wheeze; rhinitis; eczema
资金
- National Natural Science Foundation of China [51136002, 51076079]
- 12th Five-year National Key Technology RD Program [2012BAJ02B03]
- National High Technology Research and Development Program of China [2010AA064903]
- Tsinghua University Initiative Scientific Research Program [20121088010]
- China Post-doctoral Science Foundation [2012M510459]
This study evaluated the prevalence and risk factors for asthma, allergy and related symptoms; and breastfeeding patterns and durations for 5479 Beijing children aged 3-6. Parents of children in randomly selected kindergartens wrote responses to a questionnaire used previously. The study aimed to evaluate trends in the prevalence of asthma and related illnesses, and to determine whether more breastfeeding, defined as exclusive, > 6 months, was associated with reduced prevalence. Asthma has increased in this age group between 1990 and 2011, with the steepest increase in the last 2-3 years. Of the total, 14.2% (779) children were breastfed exclusively for > 6 months. The efficacy of more breastfeeding was tested in a subset with two strong risk factors, positive family history (for asthma and/or allergy) and male gender. More breastfeeding was found to be significantly protective (aOR 0.42, P < 0.05) for this subset against Doctor-diagnosed asthma (D-asthma). Protection that did not reach statistical significance was also found for this subset against Wheeze ever, Cough at night, Rhinitis ever, Doctor-diagnosed rhinitis (D-rhinitis) and Eczema. The greatest protective effects were found for girls with no family history of asthma or allergy, reaching statistical significance for Wheeze ever (aOR 0.48, P < 0.01), Cough at night (aOR 0.47, P < 0.01), D-asthma (aOR 0.14, P < 0.01) and Rhinitis ever (aOR 0.67, P < 0.05). More breastfeeding was not consistently associated with either a protective or risk effect for Eczema.
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