期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 17, 页码 5223-5227出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500346
关键词
C-C coupling; C-H functionalization; dehydrogenation; iridium complexes; N-heterocycles
资金
- EPSRC
- University of Liverpool
- EPSRC/TSB
- EPSRC [EP/K039687/1, EP/K504166/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K504166/1, EP/K039687/1] Funding Source: researchfish
A new strategy has been developed for the oxidant and base-free dehydrogenative coupling of N-heterocycles at mild conditions. Under the action of an iridium catalyst, N-heterocycles undergo multiple sp(3) C-H activation steps, generating a nucleophilic enamine that reacts in situ with various electrophiles to give highly functionalized products. The dehydrogenative coupling can be cascaded with Friedel-Crafts addition, resulting in a double functionalization of the N-heterocycles.
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