期刊
CHINESE SCIENCE BULLETIN
卷 56, 期 32, 页码 3394-3397出版社
SCIENCE PRESS
DOI: 10.1007/s11434-011-4734-2
关键词
psychosis; endophenotypes; neuropsychology; social cognition
资金
- Project-Oriented Hundred Talents Programme [O7CX031003]
- Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8]
- National Science Fund for Distinguished Young Scholars [81088001]
The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.
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