期刊
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
卷 43, 期 2-3, 页码 293-298出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-015-1675-9
关键词
Natural products; Peptaibols; LC MS/MS; Nonribosomal peptides; Informatic platforms
资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada [RGPIN 371576-2014]
- Joint Programme Initiative on Antimicrobial Resistance
- CIHR
- Canada Research Chairs Program
Natural products are a crucial source of antimicrobial agents, but reliance on low-resolution bioactivity-guided approaches has led to diminishing interest in discovery programmes. Here, we demonstrate that two in-house automated informatic platforms can be used to target classes of biologically active natural products, specifically, peptaibols. We demonstrate that mass spectrometry-based informatic approaches can be used to detect natural products with high sensitivity, identifying desired agents present in complex microbial extracts. Using our specialised software packages, we could elaborate specific branches of chemical space, uncovering new variants of trichopolyn and demonstrating a way forward in mining natural products as a valuable source of potential pharmaceutical agents.
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