期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 30, 期 -, 页码 190-196出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2015.05.021
关键词
Reduced graphene oxide; Noncovalent interaction; Folic acid; Targeted drug delivery; Anticancer drug carrier
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014055946]
Conjugate of reduced graphene oxide with folic acid (rGO/FA) was prepared through a completely noncovalent functionalization method. rGO/FA conjugate was soluble in physiological media with high dispersion stability and enabled the accumulation of hydrophobic doxorubicin (DOX) and CdSe quantum dot (QD) as an anticancer drug and a fluorescent tag, respectively. rGO/FA conjugate loaded with DOX showed specific targeting to MDA-MB 231 cells, excellent drug-release efficiency and cytotoxicity in vitro. Considering the simplicity and extendibility of noncovalent functionalization methods, rGO/FA conjugate can be widely utilized for the designing of new graphene-based nanocarriers. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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