期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 16, 页码 4915-4918出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201412283
关键词
ADP-ribosylation; phosphorylation; poly(ADP-ribose); pyrophosphates; solid-phase synthesis
资金
- Netherlands Organization for Scientific Research (NWO)
The post-translational modification of proteins that is known as adenosine diphosphate ribosylation (ADPr) regulates a wide variety of important biological processes, such as DNA-damage repair and cellular metabolism. This modification is also involved in carcinogenesis and the process of aging. Therefore, a better understanding of the function of ADP-ribosylation is crucial for the development of novel therapeutics. To facilitate the elucidation of the biology of ADPr, the availability of well-defined fragments of poly(ADP-ribose) is essential. Herein we report a solid-phase synthetic approach for the preparation of ADP-ribose oligomers of exactly defined length. The methodology is exemplified by the first reported synthesis of an ADP-ribose dimer and trimer.
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