期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 21, 期 -, 页码 1183-1190出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2014.05.032
关键词
Controlled release; Crystal engineering; Crystallization; Nanoparticles; Oral drug delivery
资金
- National Research Foundation of Korea [NRF-2013R1A1A2021573]
- National Research Foundation of Korea (Engineering Research Center) [2014-009799]
- National Research Foundation of Korea [2014R1A5A1009799] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The applicability of confined crystallization is limited by the use of extra template materials unsuitable for oral dosage forms. In consideration of this limitation, mannitol was processed into a template with well controlled pores. This template was used for the subsequent confined crystallization of a model drug, resulting in drug/mannitol composite powders processable into the common operations of oral solid dosage forms. The confined crystallization produced a significant melting point depression, caused by a significant particle size reduction, but did not alter the crystal polymorphism. The in vitro release of drug was significantly improved by the confined crystallization. (C) 2014 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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