期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 10, 页码 3033-3037出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411817
关键词
asymmetric cyclization; palladium; phosphine ligands; total synthesis; transition-metal catalysis
资金
- NSFC [21432007, 21272254]
- STCSM [13J1410900]
- Thousand Plan Youth program
A novel enantioselective palladium-catalyzed dearomative cyclization has been developed for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all-carbon quaternary center. The effectiveness of this method in the synthesis of terpenes and steroids was demonstrated by a highly efficient synthesis of a kaurene intermediate, the facile construction of the skeleton of the anabolic steroid boldenone, and the enantioselective total synthesis of the antimicrobial diterpene natural product (-)-totaradiol.
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