期刊
JOURNAL OF IMMUNOLOGY
卷 194, 期 7, 页码 2985-2991出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1403134
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资金
- Minnesota Ovarian Cancer Alliance
- Fred C. and Katherine B. Andersen Foundation
- Marsha Rivkin Foundation
- Mayo Clinic Ovarian Cancer Specialized Program of Research Excellence Award (National Institutes of Health/National Cancer Institute) [P50-CA136393]
Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immunestimulatory capacity.
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