期刊
JOURNAL OF IMMUNOLOGY
卷 195, 期 1, 页码 17-22出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500515
关键词
-
类别
T cell immunity is often defined in terms of memory lymphocytes that use the blood to access a range of organs. T cells are involved in two patterns of recirculation. In one, the cells shuttle back and forth between blood and secondary lymphoid organs, whereas in the second, memory cells recirculate between blood and nonlymphoid tissues. The latter is a means by which blood T cells control peripheral infection. It is now clear that there exists a distinct memory T cell subset that is absent from blood but found within nonlymphoid tissues. These nonrecirculating tissue-resident memory T (T-RM) cells develop within peripheral compartments and never spread beyond their point of lodgement. This review examines fixed immune surveillance by T-RM cells, highlighting features that make them potent controllers of infection in nonlymphoid tissues. These features provide clues about T-RM cell specialization, such as their ability to deal with sequestered, persisting infections confined to peripheral compartments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据