期刊
JOURNAL OF IMMUNOLOGY
卷 194, 期 9, 页码 4073-4080出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500046
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资金
- National Institutes of Health [R01 AR042547, R01 HL117913, R01 AI044142, R01 AI108906, P01 HL058000, R01 AI108891, R01 AG045779, U19 AI090019, U19 AI057266]
In studies of immune aging, naive T cells frequently take center stage. Describing the complexity of the human naive T cell repertoire remains a daunting task; however, emerging data suggest that homeostatic mechanisms are robust enough to maintain a large and diverse CD4 T cell repertoire with age. Compartment shrinkage and clonal expansions are challenges for naive CD8 T cells. In addition to population aspects, identification of potentially targetable cellular defects is receiving renewed interest. The last decade has seen remarkable progress in identifying genetic and biochemical pathways that are pertinent for aging in general and that are instructive to understand naive T cell dysfunction. One hallmark sets naive T cell aging apart from most other tissues except stem cells: they initiate but do not complete differentiation programs toward memory cells. Maintaining quiescence and avoiding differentiation may be the ultimate challenge to maintain the functions unique for naive T cells.
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