期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 29, 页码 8364-8368出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502608
关键词
DNA; electron transfer; photooxidation; ruthenium; time-resolved spectroscopy
资金
- Biotechnology and Biological Sciences Research Council [BB/K019279/1, BB/M004635/1] Funding Source: Medline
- BBSRC [BB/K019279/1, BB/M004635/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M004635/1, BB/K019279/1] Funding Source: researchfish
Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Lambda-[Ru(TAP)(2)(dppz)](2+) have been compared in 5'-{CCGG (AT) under bar CCGG}(2) and 5'-{CCGG (TA) under bar CCGG}(2) using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5'-TA-3' versus 5'-AT-3' binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.
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