期刊
CHINESE JOURNAL OF POLYMER SCIENCE
卷 27, 期 6, 页码 797-805出版社
SPRINGER
DOI: 10.1142/S0256767909004515
关键词
Dendritic PAMAM-b-PLG; pH-sensitive self-assembly; Nanoparticles; Drug/gene delivery
资金
- National Natural Science Foundation of China [20674050]
- Shanghai Leading Academic Discipline Project [B202]
Dendritic poly(amidoamine)-b-poly(L-glutamate) (PAMAM-b-PLG) biohybrids were synthesized by the ring-pening polymerization of gamma-benzyl-L-glutamate N-carboxyanhydride monomer, followed by the deprotection of benzyl groups on poly(benzyl-L-glutamate), and were characterized by H-1-NMR, FT-IR and gel permeation chromatography. The self-assembly behavior of the PAMAM-b-PLG biohybrid was investigated by means of UV-Vis, dynamic light scattering (DLS), transmission electronic microscopy (TEM) and H-1-NMR. UV-Vis analysis demonstrated that the critical aggregation concentration of PAMAM-b-PLG was dependent on the pH value of aqueous solutios. DLS results further evidenced that the PAMAM-b-PLG biohybrid exhibited a pH-sensitive self-assembly behavior, and the average size of the self-assembled nanoparticles decreased gradually with the increasing pH value of the PAMAM-b-PLG solution. The self-assembled nanoparticles gave a nearly spherical morphology, and the pH-induced self-assembly had no obvious effect on the morphology of nanoparticles.
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