期刊
CHINESE JOURNAL OF PHYSIOLOGY
卷 53, 期 6, 页码 423-429出版社
CHINESE PHYSIOLOGICAL SOC
DOI: 10.4077/CJP.2010.AMM026
关键词
Hodgkin-Huxley model; transient receptor potential (TRP); action potential; computer simulations
类别
资金
- National Science Council [NSC-94-2320B-006-019]
- Ministry of Education, Taiwan, ROC
- Cardiac Electrophysiology and Systems-biology Center
- National Cheng Kung University Medical Center, Tainan, Taiwan, ROC
Transient receptor potential vanilloid-1 (TRPV1) channels play a role in several inflammatory and nociceptive processes. Previous work showed that magnetic electrical field-induced antinoceptive action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (I-TRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage. When model neuron is exposed to low-frequency sinusoidal voltage, increased maximal conductance of I-TRP can enhance repetitive bursts of APs accompanied by a shortening of inter-spike interval (ISI) in AP firing. The change in ISIs with number of interval is periodic with the phase-locking. In addition, increased maximal conductance of I-TRP can abolish chaotic pattern of AP firing in model neuron during exposure to high-frequency voltage. The ISI pattern is converted from irregular to constant, as maximal conductance of ITRP is increased under such high-frequency voltage. Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs.
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