Progress on Transition-Metal-Catalyzed Cross-Coupling Reactions of Ammonium Salts via C-N Bond Cleavage

Amines containing carbon-nitrogen (C-N) bonds are widely distributed in natural products, drug molecules and functional materials. C-N bonds are one of the most abundant and inert bonds in organic molecules. Selective cleavage of C-N bonds to construct carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds represents a new synthetic method in organic synthesis. It is difficult for the direct cleavage of C-N bond. Ammonium salts are a series of stable compounds easily obtained from amines. The recent progress of transition-metal-catalyzed cross-coupling reactions via C-N bond cleavage using ammonium salts as starting materials is summerized.