期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 33, 期 4, 页码 799-802出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201301050
关键词
P-stereogenic compound; Pincer-Pd catalyst; methylphenylphosphine; asymmetric alkylation
资金
- National Basic Research Program of China (973 Program) [2010CB833300]
- National Natural Science Foundation of China [20902099, 21172238]
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
A bis(phosphine) (PCP) pincer palladium-catalyzed asymmetric alkylation of methylphenylphosphine with alkyl halides was developed for the synthesis of P-chiral phosphorus compounds in mild conditions. The corresponding products were obtained in high yields with moderate enantioselectivities. The possible catalytic cycle and stereochemical pathway have also been proposed via the Pincer-PdPMe(Ph) intermediate, which is generated from the reaction of Pd catalyst with methylphenylphosphine.
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