期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 33, 期 5, 页码 995-999出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201212009
关键词
1,2,4-triazolo[1,5-a]pyrimidine; 1,3,4-oxadiazole; thioether; synthesis; bioactivity
资金
- Governor's Foundation for Excellent Talents of Science, Technology AMP
- Education of Guizhou Province [200817]
- Natural Science Foundation of Guizhou Province [20082265]
Using 2-benzylthio-5-methyl-7-hydroxyl-1,2,4-triazolo[1,5-alpha]pyrimidine as starting material, ten novel 2-benzylthio-5-methyl-7-(5-substituted benzylthio-1,3,4-oxadiazol-2-yl)-methyleneoxyl-1,2,4-triazolo[1,5-a]pyrimidine derivatives 5a similar to 5j were synthesized via sequential reactions of etherification, hydrazinolysis, cyclization and thioetherification. The structures of target compounds were fully characterized by H-1 NMR, IR, MS and elemental analysis. The preliminary bioassay showed that some compounds possessed good anti-TMV (tobacco mosaic virus) or certain fungicidal activities in vitro. At the concentration of 500 mu g/mL, the inhibition rates of compounds 5b, 5f and 5j against TMV were 45%, 45% and 43%, respectively.
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