期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 33, 期 12, 页码 2460-2468出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201307014
关键词
transition metals; decarboxylative coupling; alkyl carboxylic acid; advance
资金
- National Natural Science Foundation of China [21272050, 21072040]
Carboxylic acids are cheap, readily available, easy to store and handle compounds. Since the studies of decarboxylative Heck reaction of aryl carboxylic acids, transition metal-catalyzed decarboxylative coupling reactions have become an interesting research area. Transition metal-catalyzed alkyl coupling plays an important role in the synthesis of nonplanar molecule. Thus, much attention has been paid to the development of transition metal-catalyzed decarboxylative cross-coupling reactions of alkyl carboxylic acids. This review focuses on: (1) the copper-catalyzed decarboxylative coupling reaction between proline derivatives and nucleophilies including terminal alkynes (C-sp3-C-sp), indoles (C-sp3-C-sp2) and nitromethane (C-sp3-C-sp2), the copper-catalyzed decarboxylative aldol reaction of thioester derivatives, the copper-catalyzed decarboxylative Mannich-type reaction; the copper-catalyzed decarboxylative alkynylation of quaternary a-cyano acetate salts; (2) the palladium-caytalyzed decarboxylative couplings of 2-(2-azaaryl)acetates, cyanoacetate, salts, nitrophenyl acetates salts with aryl halides; (3) the silver-catalyzed decarboxylative chlorination, fluorination and alkynylation.
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