期刊
JOURNAL OF IMMUNOLOGY
卷 195, 期 6, 页码 2520-2523出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500344
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资金
- National Institutes of Health [P01 CA154778]
- Van Kampen Cardiopulmonary Research Fund
The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D-3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
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