期刊
JOURNAL OF IMMUNOLOGY
卷 194, 期 6, 页码 2455-2465出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1402794
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- National Health and Medical Research Council of Australia [APP1051742]
Type I IFNs are known to inhibit viral replication and mediate protection against viral infection. However, recent studies revealed that these cytokines play a broader and more fundamental role in host responses to infections beyond their well-established antiviral function. Type I IFN induction, often associated with microbial evasion mechanisms unique to virulent microorganisms, is now shown to increase host susceptibility to a diverse range of pathogens, including some viruses. This article presents an overview of the role of type I IFNs in infections with bacterial, fungal, parasitic, and viral pathogens and discusses the key mechanisms mediating the regulatory function of type I IFNs in pathogen clearance and tissue inflammation.
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