Visible Light-Induced Methoxycarbonyldifluoromethylation of Trimethylsilyl Enol Ethers and Allyltrimethylsilanes with FSO2CF2CO2Me

A photocatalytic methoxycarbonyldifluoromethylation of trimethylsilyl enol ethers with FSO2CF2CO2Me in the presence of fac-Ir(ppy)(3) was developed. This reaction provided a practical strategy for the construction of various -CF2CO2R aromatic ketones, which are difficult to access by other methods. Furthermore, a series of methoxycarbonyldifluoromethylated allylic compounds could also be obtained from allyltrimethylsilanes using the same strategy. The resulting CF2CO2R-containing products are useful building blocks and potentially valuable in medicinal chemistry and material sciences.