Asymmetric Pudovik Reaction of Chiral Fluoroalkyl α,β-Unsaturated Ketimines and Diphenyl Phosphite

The asymmetric Pudovik reaction of chiral fluoroalkyl ,-unsaturated ketimines derivated from (R)-tert-butanesulfinamide and diphenyl phosphite was achieved in the presence of Rb2CO3 at room temperature. A series of fluoroalkylated -amino phosphonates were prepared in good yields with high diastereoselectivities.