An Efficient Palladium and Bis(2-pyridylmethyl)amine-based System for Suzuki-Miyaura Cross-Coupling under Aqueous and Aerobic Condition

A novel PdCl2/bis(2-pyridylmethyl)amine-based ligand (1) catalytic system, which is water-soluble and air-stable, has been successfully synthesized and applied for Suzuki-Miyaura cross-coupling reaction. In the presence of catalytic amount of PdCl2/1 system, arylboronic acids can couple with a wide range of aryl halides, including aryl bromides and aryl chlorides. The reactions proceed under mild conditions to give excellent yields, and a wide range of functionalities is tolerated.