Cembranoid, Steroid, and Sesquiterpenoid Derivatives from the South China Sea Soft Coral Sinularia numerosa

Two new cembranoids, namely, sinumerolides A and B (1 and 2), one new steroid, 7 beta-hydroxygorgosterol (7), along with four known cembranoid derivatives (36), four known steroids (811), and four known africane sesquiterpenoids (1215), were isolated and identified from the marine soft coral Sinularia numerosa that was collected from South China Sea waters. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of their spectral data with those of literature reports. The isolated compounds were evaluated for the antimicrobial and cytotoxic activity.