Gallium(III) Iodide-catalyzed Biginelli-type Reaction Under Solvent-free Conditions: Efficient Synthesis of Dihydropyrimidine-2(1H)-one Derivatives

The Biginelli-type condensation of ethyl acetoacetate/cycloketone, aldehyde and urea/thiourea under solvent-free condition catalyzed by 10% gallium(III) iodide to form dihydropyrimidine-2(1H)-one derivatives was described. This process offered one way to constructing dihydropyrimidine-2(1H)-ones in good to excellent yields with simple procedure and short reaction time.