Al(H2PO4)3 as an Efficient and Reusable Catalyst for One-pot Three-component Synthesis of α-Amino Phosphonates under Solvent-free Conditions

Synthesis of alpha-amino phosphonates is described under solvent-free conditions at 100 degrees C from reaction between aldehydes and amines in the presence of trialkyl phosphites using Al(H2PO4)(3) as an efficient and reusable heterogeneous catalyst. The advantages of this procedure are short reaction time, flexibility and having high to excellent yields.