期刊
CHINESE CHEMICAL LETTERS
卷 30, 期 2, 页码 431-434出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.08.015
关键词
Penicillium sumatrense; Garcinia multiflora; Pyridones; Antibacterial activities; Endophytic fungi
资金
- 100 Leading Talents of Guizhou Province
- Science and Technology Project of Guizhou [QKHT Z-2014-4007]
- Academician Workstation of Guizhou [QKH YSZ-2015-4009]
- QKH [YSZ-2015-4009]
Citridones E-G (1-3), three new phenylpyridone derivatives together with two known curvularins (4 and 5) were isolated from the solid culture of the endophytic fungus Penicillium sumatrense GZWMJZ-313 in Garcinia multiflora. The structures of new compounds were determined in the light of spectroscopic data, X-ray and ECD calculation. Compounds 1 and 3 are racemates, while compound 2 is optically pure. Compounds 1 and 4 showed antibacterial and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium perfringens, Escherichia coli and Candida albicans with MIC values ranging from 8 mu g/mL to 64 mu g/mL. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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