期刊
CHINESE CHEMICAL LETTERS
卷 25, 期 9, 页码 1296-1300出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.04.019
关键词
1,2-Disubstituted acetylene; Nickel; (Bromoethynyl)benzene; Grignard reagent; Cross-coupling
资金
- Fundamental Research Funds for the Central Universities, Southwest University for Nationalities [12NZYTH03]
- Natural Science Foundation of Southwest University for Nationalities [381010]
- Project of Postgraduate Degree Construction, Southwest University for Nationalities [2013XWD-S0703]
- State Administration of Foreign Experts Affairs project [2012-10]
We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl2 (4 mol%) and (p-CH3Ph)(3)P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature. (C) 2014 Qing-Han Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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