A green multicomponent synthesis of bioactive pyrimido[4,5-b]quinoline derivatives as antibacterial agents in water catalyzed by RuCl3•xH2O

An efficient, convenient and environmentally benign one-pot multicomponent reaction for the preparation of pyrimido[4,5-b]quinoline derivatives as biologically, pharmacologically and antibacterially active products has been developed using RuCl3 center dot xH(2)O as a reusable homogenous catalyst. Use of water as a green solvent, purification of products by non-chromatographic methods, reusability of transition metal homogenous catalyst, saving energy by employing multicomponent reactions, short reaction times and high yields, are some of the advantages of this process. (C) 2013 Khalil Tabatabaeian. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.