Two new eupodienone lignans from Gymnotheca chinensis

Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound 1 was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 mu mol/L. (C) 2013 Li-Sheng Ding and Yan Zhou. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.