DABCO-promoted facile and convenient synthesis of novel isoxazolyl-1H-2,3-pyrrole dicarboxylates

Synthesis of isoxazolyl-1H-2,3-pyrrole dicarboxylate (4) was simply achieved by one-pot three component reaction of isoxazole amine (1) with diethyl acetylenedicarboxylate (DEAD) (2), and glyoxal (3), in acetonitrile catalyzed by diazabicyclo octane (DABCO). (C) 2013 Rajanarendar Eligeti. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.