期刊
CHINESE CHEMICAL LETTERS
卷 24, 期 3, 页码 227-229出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2013.01.041
关键词
Antimicrobial activity; Bipyridinyl coumarins; Coumarins; Krohnke's reaction
资金
- UGC, New Delhi, India
As a part of the ongoing studies in developing new antimicrobials, a series of structurally novel 3-bipyridinyl substituted coumarin derivatives 4a-f and 5a-f were synthesized by a single-step reaction protocol under Krohnke's reaction conditions. H-1 NMR, C-13 NMR, IR and mass spectral techniques were employed for the structural elucidation of the synthesized compounds. An evaluation of antimicrobial activity showed that almost all compounds exhibited better results than the referenced drugs. Among the synthesized derivatives 4f, 5a and 5d were found to be the most potent analogs. Thus they could be promising lead for novel drugs. (C) 2013 D.I. Brahmbhatt. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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