期刊
CHINESE CHEMICAL LETTERS
卷 24, 期 8, 页码 710-714出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2013.05.011
关键词
PLGA microspheres; Controlled release; Hydrogel; Cell compatibility
资金
- Natural Science Foundation of China [21004074, 51103172, 212101064]
- Hundred Talents Program of the Chinese Academy of Sciences
- Ningbo Natural Science Foundation [2011A610120, 2012A610176]
- Program for Ningbo Innovative Research Team [2012E82019]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
This letter reports on the fabrication of hollow, porous and non-porous poly(D,L-lactide-co-glycolide) (PLGA) microspheres (MSs) for the controlled release of protein and promotion of cell compatibility of tough hydrogels. PLGA MSs with different structures were prepared with modified double emulsion methods, using bovine serum albumin (BSA) as a porogen during emulsification. The release of the residual BSA from PLGA MSs was investigated as a function of the MS structure. The hollow PLGA MSs show a faster protein release than the porous MSs, while the non-porous MSs have the slowest protein release. Compositing the PLGA MSs with poly(vinyl alcohol) (PVA) hydrogels promoted chondrocyte adhesion and proliferation on the hydrogels. (C) 2013 Jun Fu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据