期刊
CHINESE CHEMICAL LETTERS
卷 21, 期 5, 页码 550-553出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2010.01.032
关键词
Quinazolinones; Aromatic aldehydes; Tetrabutylammonium bromide (TBAB); Copper (II) chloride (CuCl2); Microwave irradiation
A simple and efficient procedure for the synthesis of 2-arylquinazolin-4(3H)-ones has been developed through cyclocondensation of 2-aminobenzamide with aromatic aldehydes using tetrabutylammonium bromide (TBAB) as novel neutral ionic liquid catalyst in the presence of copper (II) chloride (CuCl2) as oxidizing agent under solvent-free conditions at 100 degrees C. In the absence of CuCl2 and under a nitrogen atmosphere, the unoxidized intermediates, 2-aryl-2,3-dihydroquinazolin-4(1H)-ones, were isolated. Treatment of these intermediates with CuCl2 in TBAB media gave the oxidized products 2-arylquinazolin-4(3H)-ones On the other hand, cyclocondensation of 2-aminobenzamide with aromatic aldehydes in TBAB under microwave irradiation directly gave 2-arylquinazolin-4(3H)-ones. (C) 2010 A. Davoodnia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved
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