期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 49, 页码 14941-14946出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508221
关键词
alkynes; carbenes; cyclizations; reaction mechanisms; silver
资金
- Shanghai Pujiang Talent Program [11PJ1402500]
- National Natural Science Foundation of China [21171056]
A silver-catalyzed amidiniumation of N-propiolic formamidines for the synthesis of novel enamine amido carbene precursors is reported. Isolation of a first silver intermediate in silver-catalyzed amidiniumation of alkynes and other organogold intermediates supports our proposed mechanisms. Several control experiments reveal the unexpected effects of both HOTf and substrate substituents on the choice of either a pi or sigma, pi silver activation mode and the cyclization fashion. Bis(hydroxyimidazol)ium salts were obtained through an unprecedented umpolung of propiolamides. The byproduct Ag2O as either an oxidant or silver source promotes the syntheses of N-heterocyclic carbene (NHC) precursors or Ag/NHC complexes.
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