期刊
CHIMIA
卷 63, 期 3, 页码 134-139出版社
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2009.134
关键词
DNA; Fluorescence; G-quadruplex; Nucleic acids; Tetraplex
资金
- Swiss National Science Foundation [116868]
- University of Zurich
Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered. Cell-permeable G-quadruplex specific probes should provide researchers with new tools for studying these alternately folded DNA structures and their potential involvement in gene expression, chromosome stability, viral integration, and recombination. In this review, a survey of the binding affinity, specificity, and biological/pharmacological activities of some well-characterized G-quadruplex ligands is presented along with the potential importance of G-quadruplex DNA in vivo.
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