期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 39, 页码 11424-11427出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504076
关键词
cyclohexenes; iridium catalyst; N-aryl cyclobutyl amines; photocatalysis; small ring systems
资金
- University of Arkansas, Arkansas Bioscience Institute
- National Institutes of Health (NIH) from National Institute of General Medical Sciences [P30 GM103450]
- NSF Career Award [CHE-1255539]
We report the first example of an intermolecular [4+2] annulation of cyclobutylanilines with alkynes enabled by visible-light photocatalysis. Monocyclic and bicyclic cyclobutylanilines successfully undergo the annulation with terminal and internal alkynes to generate a wide variety of amine-substituted cyclohexenes including new hydrindan and decalin derivatives with good to excellent diastereoselectivity. The reaction is overall redox neutral with perfect atom economy.
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