期刊
CHEST
卷 144, 期 1, 页码 79-86出版社
ELSEVIER SCIENCE BV
DOI: 10.1378/chest.12-2829
关键词
-
资金
- Mayo Foundation
- Mayo Clinic Clinician-Investigator Training Program
- National Heart Lung and Blood Institute [096071]
- National Institutes of Health (NIH) [R201 HL096071, R01 HL114024]
- National Center for Research Resources (NCRR), a component of the NIH and the NIH Roadmap for Medical Research [1ULI RR024150]
- Czech Ministry of Health [NS 10098-4/2008]
- European Regional Development Fund [FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]]
Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insufficient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by +559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of +677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction Was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction. Trial Registration: ClinicalTrials.gov; No.: NCT01334788; URL: www.clinicaltrials.gov
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据