期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 36, 页码 10618-10622出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504254
关键词
cross-coupling; isocyanides; isomerization; radicals; silver
资金
- NSFC [21372038, 21202016, 21172029]
- Ministry of Education of the People's Republic of China [NCET-13-0714]
- Jilin Provincial Research Foundation for Basic Research [20140519008JH]
Isocyanides are versatile building blocks, and have been extensively exploited in CH functionalization reactions. However, transition-metal-catalyzed direct CH functionalization reactions with isocyanides suffer from over-insertion of isocyanides. Reported herein is a radical coupling/isomerization strategy for the cross-coupling of isocyanides with active methylene compounds through silver-catalysis. The method solves the over-insertion issue and affords a variety of otherwise difficult to synthesize -aminoenones and tricarbonylmethanes under base- and ligand-free conditions. This report presents a new fundamental CC bond-forming reaction of two basic chemicals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据