期刊
CHEMSUSCHEM
卷 7, 期 6, 页码 1612-1617出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201301282
关键词
flow chemistry; heterocycles; homogeneous catalysis; photochemistry; ruthenium
资金
- Dutch Science Foundation [12464]
- European Union
- Advanced European Research Council [267443, 227010]
- European Research Council (ERC) [227010] Funding Source: European Research Council (ERC)
Trifluoromethylated and perfluoroalkylated heterocycles are important building blocks for the synthesis of numerous pharmaceutical products, agrochemicals and are widely applied in material sciences. To date, trifluoromethylated and perfluoroalkylated hetero-aromatic systems can be prepared utilizing visible light photoredox catalysis methodologies in batch. While several limitations are associated with these batch protocols, the application of microflow technology could greatly enhance and intensify these reactions. A simple and straightforward photocatalytic trifluoromethylation and perfluoroalkylation method has been developed in continuous microflow, using commercially available photocatalysts and microflow components. A selection of five-membered hetero-aromatics were successfully trifluoromethylated (12examples) and perfluoroalkylated (5examples) within several minutes (8-20min).
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