期刊
CHEMSUSCHEM
卷 1, 期 4, 页码 333-338出版社
WILEY-BLACKWELL
DOI: 10.1002/cssc.200700160
关键词
alkynes; amines; homogeneous catalysis; hydroamination; zinc
Catalytic hydroominations are one of the most sustainable C-N bond-forming processes as a result of 100% atom economy and the availability of substrates. Here, it is shown that the intermoleculor hydroamination of terminal alkynes with anilines proceeds smoothly in the presence of catalytic amounts of zinc triflate, an easily available and inexpensive zinc salt. Amination and subsequent reduction with NaBH(3)CN gives a variety of secondary and tertiary amines in up to 99% yield and with over 99% Markovnikov regioselectivity. Moreover, difficult functional groups such as nitro and cyano substituents are tolerated by the homogeneous catalyst.
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