期刊
CHEMPHYSCHEM
卷 11, 期 3, 页码 730-735出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.200900849
关键词
fluorescence; fluorophore; ion sensors; nanoparticles; polymers
资金
- German Research Foundation (DFG) [SPP 1313, 794/4-1]
- Groupement d'interet Public-Agence Nationale de la Recherche (GIP-ANR)
- PNANO [05-NANO-051]
- German Academic Exchange Service (DAAD) [D/0707567]
- French Ministry of Foreign Affairs (EGIDE)
Ion sensors based on colloidal nanoparticles (NPs), either as actively ion-sensing NPs or as nanoscale carrier systems for organic ion-sensing fluorescent chelators, typically require a charged surface in order to be colloidally stable. We demonstrate that this surface charge significantly impacts the ion binding and affects the read-out. Sensor re ad-out should be thus not determined by the bulk ion concentration, but by the local ion concentration in the nano-environment of the NP surface. We present a conclusive model corroborated by experimental data that reproduces the strong distance-dependence of the effect. The experimental data are based on the capability of tuning the distance of a pH-sensitive fluorophore to the surface of NPs in the nanometer (nm) range. This in turn allows for modification of the effective acid dissociation constant value (its logarithmic form, pK(a)) of analyte-sensitive fluorophores by tuning their distance to the underlying colloidal NPs.
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