期刊
CHEMOSPHERE
卷 211, 期 -, 页码 648-652出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.08.010
关键词
Arsenite; Zebrafish; Oxidative stress; Oxidative damage; Apoptosis
资金
- National Nature Science Foundation of China [21707123]
- Foundation of Science and Technology Bureau of Jinhua [2017-4-094]
- Zhejiang Xinmiao Talent Projects [2017R404024]
Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 mu g L-1) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes. Our study showed that chronic exposure to AsIII concentrations <150 mu g L-1 generated oxidative stress and damage on zebrafish, and altered apoptosis-related genes in zebrafish. (C) 2018 Elsevier Ltd. All rights reserved.
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