4.7 Article

Urinary levels of bisphenol analogues in residents living near a manufacturing plant in south China

期刊

CHEMOSPHERE
卷 112, 期 -, 页码 481-486

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2014.05.004

关键词

Bisphenol analogues; Biomonitoring; Urine; Liquid chromatography; Mass spectrometry

资金

  1. National Natural Science Foundation of China [41273132, 21207008, 21307006]

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The use of bisphenol A (BPA) has been restricted in many countries because of its potential health effects. As a result of these restrictions, a group of bisphenol analogues that are structurally similar to BPA have been developed as the alternatives for industrial applications. However, latest researches indicated that these chemicals have similar endocrine-disrupting effects as BPA in humans. Moreover, only a limited number of studies have attempted to monitor the exposure level in humans of other bisphenol analogues. In the present study, the concentrations of seven bisphenols, including bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), BPA, bisphenol AF (BPAF), tetrachlorobisphenol A (TCBPA) and tetrabromobisphenol A (TBBPA), in human urine samples were measured by liquid chromatography coupled to mass spectrometry (LC-MS/MS) following the enzymatic hydrolysis of glucuronidase/arylsulfatase and liquid-liquid extraction (LLE). Under the optimised conditions, high recoveries (81.6-116.8%) were obtained for all the analytes, and the relative standard deviations (RSD, %) were less than 16.4% (n = 6). The isotopic internal standard calibration curves for each of the target compounds exhibited excellent linearity (r(2) > 0.99) and the limit of quantification (LOQ) for the analytes in urine ranged from 0.024 to 0.310 ng mL(-1). The method was applied to investigate the urinary levels of these seven bisphenols in a cohort of residents living near a BPAF manufacturing plant in south China. BPS, BPF, BPA and BPAF were detected in urine samples at concentrations ranging from

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