期刊
CHEMOSPHERE
卷 91, 期 8, 页码 1203-1212出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2013.01.037
关键词
Fluoride uptake; Oxidative stress; Histopathological changes; Apoptosis; Bcl-2 and Bax expression; Cyprinus carpio
资金
- International Cooperation Project from Ministry of Science and Technology [2010DFB30530-1]
- National Natural Science Foundation of China [31172376]
- Shanxi Province Natural Science Foundation Project [2009021038]
- Postdoctoral Science Foundation of China [2012M520601]
- Doctor Initial Funding of Shanxi Agricultural University [XB2009003]
- Postdoctoral Science Foundation of Shanxi Agricultural University [92462]
- Science and Technology Innovational Funding of Shanxi Agricultural University [2009005]
Fish take up fluoride directly from water and are the target organisms for fluoride pollution in the aquatic ecosystems. This study was conducted to evaluate oxidative stress, histopathological changes, apoptosis and Bcl-2, Bax expression in the livers of the common carp (Cyprinus carpio) chronically exposed to fluoride. Our results showed that after 90 d of exposure, the inhibition of SOD, GSH activities and a dose-dependent stimulation of MDA levels in the liver tissues indicated that fluoride caused oxidative stress in the fish. Microscopic examinations showed that damages to the liver tissues and cell organelles in the liver tissues increased with exposure concentration. A positive correlation was observed between the apoptosis index and fluoride levels in the livers (r = 0.995). There was a negative correlation between the fluoride concentration of water and the expression of Bcl-2, Bcl-2/Bax (r = -0.98, r = -0.96). A positive correlation was showed between the fluoride concentration of water and the expression of Bax (r = 0.96) after 90 d of exposure. Our results suggested that the common carp could tolerate relatively high levels of fluoride but adverse effects of fluoride occurred in the livers of the fish after 90 d of exposure. The apoptosis of liver cells had an important causative role in the process of fluoride-induced pathological changes of liver. (C) 2013 Elsevier Ltd. All rights reserved.
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