期刊
CHEMOSPHERE
卷 83, 期 4, 页码 461-467出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2010.12.069
关键词
Acute toxicity; Bioaccumulation; Chronic toxicity; Microarry; Reproduction; Zebrafish; TiO2; Nanoparticles
资金
- U.S. Environmental Protection Agency Science [RD831713]
- National Science Foundation [0812551]
- Direct For Computer & Info Scie & Enginr
- Div Of Information & Intelligent Systems [0812551] Funding Source: National Science Foundation
As common engineered nanomaterials, TiO2 nanoparticles (nTiO(2)) are usually perceived as non-toxic, and have already been widely used in many products and applications. Such a perception might have been shaped by some short-term studies that revealed no/low toxicity of nTiO(2) to cells and eco-relevant organisms. However, given the ultimate release of nTiO(2) into the aquatic environment, which can act as a sink for engineered nanoparticles, their long-term impact on the environment and human health is still a concern and deserves more research efforts. Here, for the first time, we demonstrate that chronic exposure of zebrafish to 0.1 mg L-1 nTiO(2), can significantly impair zebrafish reproduction. For instance, there was a 29.5% reduction in the cumulative number of zebrafish eggs after 13 weeks of nTiO(2) exposure. Thus, we provided timely information on indicating a serious risk of reproductive impairment of environments contaminated with low levels of nTiO(2) on aquatic organisms, leading to alterations in population dynamics and aquatic ecosystem balance, and thus warrants a careful scrutiny on toxicity assessment of nTiO(2), especially their long-term impact. (C) 2010 Elsevier Ltd. All rights reserved.
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